Salesian College values the contribution Music plays in the life of the school. Instrumental students, in particular, benefit immensely from this enhanced profile in the school community. Band rehearsals engender a welcoming and supportive environment and the students' confidence is raised through the varied performing opportunities.

The College currently has some 250 students involved in the Instrumental Music Program. Tuition is provided on a large range of instruments including Flute, Oboe, Clarinet, Saxophone, French Horn, Trumpet, Trombone, Tuba, Piano, Guitar and Bass Guitar and Drums/Percussion. Students are given one free semester of instrumental tuition in Year 7 as part of their Classroom Music curriculum. Students can then elect to continue on their instrument or change to another.

A major aspect of the Instrumental Music program is the ensemble work. Salesian College has four ensembles that cater for different levels of student ability. These comprise the Senior and Intermediate Concert and Stage Bands. All Bands attend an annual Music Camp and perform a number of times each year. The opportunities for public performances include school liturgies, assemblies, evening concerts and presentations for the wider community. Major highlights for the College bands have included the Olympic Torch Relay, State Ministerial performances, Band Festivals and Eisteddfods. More intimate performances take the form of Soirees where students can gain confidence performing as soloists or in a small ensemble group.